Protein Name:
E3 ubiquitin-protein ligase RNF114
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UniprotKB/SwissProt ID: Q9Y508 (Q9Y508)
Gene Name:
RNF114
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates (PubMed:23645206, PubMed:25165885). In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity (PubMed:25165885, PubMed:28708287). Acts as a negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 (PubMed:25165885). May promote the ubiquitination of TRAF6 as well (PubMed:28708287). Also acts as a negative regulator of T-cell activation (PubMed:25165885). Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation (PubMed:25165885). Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C (PubMed:23645206). This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Y508
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
143 |
RNVPNRYTFP C PYCPEKNFDQ |
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| 2 |
160 |
NFDQEGLVEH C KLFHSTDTKS |
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| 3 |
176 |
TDTKSVVCPI C ASMPWGDPNY |
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| 4 |
67 |
LKPKKPVCGV C RSALAPGVRA |
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| 5 |
8 |
---MAAQQRD C GGAAQLAGPA |
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| 6 |
91 |
ERQIESTETS C HGCRKNFFLS |
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