Protein Name:
Ribosomal biogenesis protein LAS1L
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UniprotKB/SwissProt ID: Q9Y4W2 (Q9Y4W2)
Gene Name:
LAS1L
Organism: Homo sapiens (Human)
Function: Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Y4W2
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
140 |
KTKFAKVPLK C LAQEVNIPDW |
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| 2 |
256 |
SKGSEEVDSH C KKALSHKELY |
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| 3 |
306 |
AWNNPSPRVE C VLAELKGVTC |
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| 4 |
456 |
EARRGWRLFN C SASLDWPRMV |
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| 5 |
474 |
RMVESCLGSP C WASPQLLRII |
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| 6 |
60 |
EWDQVTVYLF C DDHKLQRYAL |
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| 7 |
690 |
VLEQRLEPST C KTDTLGLSCG |
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| 8 |
706 |
GLSCGVGSGN C SNSSSSNFEG |
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