Protein Name:
Telomere length regulation protein TEL2 homolog
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UniprotKB/SwissProt ID: Q9Y4R8 (Q9Y4R8)
Gene Name:
TELO2
Organism: Homo sapiens (Human)
Function: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Membrane. Nucleus. Chromosome, telomere
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Y4R8
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
141 |
GRLAVLMEAQ C RQQTQPGFIL |
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| 2 |
30 |
SSSEDGGHIF C TLESLKRYLG |
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| 3 |
367 |
QRHVSKAVLI C LAQLGEPELR |
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| 4 |
518 |
SSKAPAYVRD C VEALTTSEDI |
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| 5 |
568 |
KVLLHLEEKT C VVGFAGLRQR |
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| 6 |
644 |
QPGSPSPNTP C LPEAAVSQPG |
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