\
logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Talin-1
UniprotKB/SwissProt ID: Q9Y490 (Q9Y490)

Gene Name: TLN1

Organism: Homo sapiens (Human)

Function: High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Cell surface. Cell junction, focal adhesion

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR036723 Alpha-catenin/vinculin-like_sf
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR032425 FERM_f0
IPR035964 I/LWEQ_dom_sf
IPR002558 ILWEQ_dom
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR037438 Talin1/2-RS
IPR015224 Talin_cent
IPR036476 Talin_cent_sf
IPR054082 Talin_IBS2B
IPR049108 Talin_R4
IPR054060 TLN1-like_RS
IPR029071 Ubiquitin-like_domsf
IPR015009 Vinculin-bd_dom
The S-nitrosylation sites of Q9Y490
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1023 DQASAMQLSQ C AKNLGTALAE  CCEEEEEEEE C CEEECCCCCC  5.38%
2 1045 RTAAQKAQEA C GPLEMDSALS  CCEEEEEEEE C CEEECCCCCC  5.92%
3 1087 KPLPGETMEK C TQDLGNSTKA  CCEEEEEEEE C CEEECCCCCC  2.35%
4 116 KTVTDMLMTI C ARIGITNHDE  CCEEEEEEEE C CEEECCCCCC  1.21%
5 1199 AKAVTQALNR C VSCLPGQRDV  CCEEEEEEEE C CEEECCCCCC  2.28%
6 1392 QPINDMSYFG C LDSVMENSKV  CCEEEEEEEE C CEEECCCCCC  2.46%
7 1434 DAISTASKAL C GFTEAAAQAA  CCEEEEEEEE C CEEECCCCCC  5.14%
8 1478 ARANQAIQMA C QSLGEPGCTQ  CCEEEEEEEE C CEEECCCCCC  2.07%
9 1939 ALVTKAGALQ C SPSDAYTKKE  CCEEEEEEEE C CEEECCCCCC  7.22% 22178444
10 1953 DAYTKKELIE C ARRVSEKVSH  CCEEEEEEEE C CEEECCCCCC  2.57%
11 2161 EHIRQELAVF C SPEPPAKTST  CCEEEEEEEE C CEEECCCCCC  5.5%
12 2408 RMVAAATNNL C EAANAAVQGH  CCEEEEEEEE C CEEECCCCCC  3.48%
13 286 ERKIFQAHKN C GQMSEIEAKV  CCEEEEEEEE C CEEECCCCCC  4.83% 2212679
14 29 FEPSTMVYDA C RIIRERIPEA  CCEEEEEEEE C CEEECCCCCC  2.68% 2212679
15 709 QTQVIAAATQ C ALSTSQLVAC  CCEEEEEEEE C CEEECCCCCC  3.41%
16 732 VVAPTISSPV C QEQLVEAGRL  CCEEEEEEEE C CEEECCCCCC  4.12%
17 750 GRLVAKAVEG C VSASQAATED  CCEEEEEEEE C CEEECCCCCC  1.06%
18 956 AGPQPLLVQS C KAVAEQIPLL  CCEEEEEEEE C CEEECCCCCC  1.51%