Protein Name:
HBS1-like protein
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UniprotKB/SwissProt ID: Q9Y450 (Q9Y450)
Gene Name:
HBS1L
Organism: Homo sapiens (Human)
Function: GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Y450
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
469 |
SELTKWYKGL C LLEQIDSFKP |
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| 2 |
491 |
QRSIDKPFRL C VSDVFKDQGS |
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| 3 |
504 |
DVFKDQGSGF C ITGKIEAGYI |
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