Protein Name:
RING finger protein 11
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UniprotKB/SwissProt ID: Q9Y3C5 (Q9Y3C5)
Gene Name:
RNF11
Organism: Homo sapiens (Human)
Function: Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Early endosome. Recycling endosome. Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Y3C5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
4 |
-------MGN C LKSPTSDDIS |
CCCCCCCCCC C CCHHHCHHHC |
4.13% |
24105792
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