Protein Name:
Oligoribonuclease, mitochondrial
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UniprotKB/SwissProt ID: Q9Y3B8 (Q9Y3B8)
Gene Name:
REXO2
Organism: Homo sapiens (Human)
Function: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (PubMed:23741365, PubMed:30926754, PubMed:31588022, PubMed:32365187). Binds and degrades longer oligonucleotides with a lower affinity (PubMed:30926754, PubMed:31588022, PubMed:32365187). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (PubMed:30926754, PubMed:31588022, PubMed:32365187). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (PubMed:31588022). Essential for embryonic development (By similarity) 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion intermembrane space. Mitochondrion matrix. Mitochondrion. Cytoplasm. Nucleus. Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Y3B8
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
97 |
DELLDSMSDW C KEHHGKSGLT |
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