Protein Name:
Nitric oxide synthase-interacting protein
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UniprotKB/SwissProt ID: Q9Y314 (Q9Y314)
Gene Name:
NOSIP
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Y314
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
185 |
KLEKPSRTVT C PMSGKPLRMS |
CCCCCCCCCC C CEEEEECCCC |
2.01% |
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| 2 |
223 |
GLITRSERYV C AVTRDSLSNA |
CCCCCCCCCC C CEEEEECCCC |
1.54% |
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| 3 |
236 |
TRDSLSNATP C AVLRPSGAVV |
CCCCCCCCCC C CEEEEECCCC |
3.39% |
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| 4 |
53 |
FDCCCLSLQP C HDPVVTPDGY |
CCCCCCCCCC C CEEEEECCCC |
3.52% |
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| 5 |
8 |
---MTRHGKN C TAGAVYTYHE |
CCCCCCCCCC C CEEEEECCCC |
2.92% |
22178444
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