Protein Name:
Phosphatidylinositide phosphatase SAC2
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UniprotKB/SwissProt ID: Q9Y2H2 (Q9Y2H2)
Gene Name:
INPP5F
Organism: Homo sapiens (Human)
Function: Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane, clathrin-coated pit. Early endosome. Recycling endosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Y2H2
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
268 |
SPETPPQEST C VDDIHPRFLV |
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