Protein Name:
Integral membrane protein 2B
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UniprotKB/SwissProt ID: Q9Y287 (Q9Y287)
Gene Name:
ITM2B
Organism: Homo sapiens (Human)
Function: Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42 Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus membrane. Cell membrane. Endosome membrane. Secreted. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Y287
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
38 |
IIPPDAVAVD C KDPDDVVPVG |
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