UniprotKB/SwissProt ID: Q9Y281 (Q9Y281)
Gene Name:
CFL2
Organism: Homo sapiens (Human)
Function: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus matrix. Cytoplasm, cytoskeleton
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