Protein Name:
Phospholipase A-2-activating protein
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UniprotKB/SwissProt ID: Q9Y263 (Q9Y263)
Gene Name:
PLAA
Organism: Homo sapiens (Human)
Function: Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Synapse
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Y263
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
116 |
YILKGHKNTV C SLSSGKFGTL |
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| 2 |
12 |
TSGATRYRLS C SLRGHELDVR |
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| 3 |
193 |
CERTFSGHED C VRGLAILSET |
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| 4 |
208 |
AILSETEFLS C ANDASIRRWQ |
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| 5 |
263 |
RSLRIWKHGE C AQTIRLPAQS |
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| 6 |
27 |
HELDVRGLVC C AYPPGAFVSV |
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| 7 |
584 |
ILLEKILSLI C NSSSEKPTVQ |
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| 8 |
605 |
QLQILWKAIN C PEDIVFPALD |
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| 9 |
631 |
IKHPSVNENF C NEKEGAQFSS |
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| 10 |
664 |
ANQLLALRTF C NCFVGQAGQK |
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