UniprotKB/SwissProt ID: Q9XIE2 (Q9XIE2)
Gene Name:
ABCG36
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with ABCG37, regulates auxin homeostasis and responses by playing a dual role in coumarin (e.g. esculin) and in the auxin precursor indole 3-butyric acid (IBA) efflux transport, thus influencing cotyledons, roots and root hairs development (PubMed:19648296, PubMed:20498067, PubMed:26517905, PubMed:28623273). Mediates the transport (export into the apoplast) of distinct indole-type metabolites in distinct biological processes; a precursor of 4-O-beta-D-glucosyl-indol-3-yl formamide (4OGlcI3F), a pathogen-inducible tryptophan-derived compound (e.g. upon Blumeria graminis conidiospore inoculation), being a probable substrate in extracellular pathogen defense (PubMed:26023163). Involved in the cellular detoxification of xenobiotics by promoting the excretion of some auxinic herbicides including 4-(2,4-dichlorophenoxy)butyric acid (2,4-DB) and other members of the phenoxyalkanoic acid family but not 2,4-dichlorophenoxyacetic acid (2,4-D) (PubMed:20498067). Mediates thymidine exudation in the rhizosphere (PubMed:28623273). May be a transporter of lignin precursors during tracheary element differentiation (PubMed:28921082). Key factor that controls the extent of cell death in the defense response (PubMed:24889055). Necessary for both callose deposition and glucosinolate activation in response to pathogens (PubMed:23815470, PubMed:26023163). As a central component of nonhost resistance (NHR), required for limiting invasion by nonadapted pathogens including powdery mildews (e.g. Blumeria graminis and Erysiphe pisi), root-penetrating pathogenic fungi (e.g. Fusarium oxysporum), Phakopsora pachyrhizi and Colletotrichum gloeosporioides (anthracnose fungi), probably by sensing Ca(2+) via interactions with calmodulins (e.g. CaM7) (PubMed:20605856, PubMed:24889055, PubMed:26023163, PubMed:26315018, PubMed:29085068). Confers resistance to cadmium (Cd) and lead (Pb), probably as an efflux pump of Cd2+ or Cd conjugates, and possibly, of chemicals that mediate pathogen resistance. Promotes resistance to abiotic stresses (e.g. drought and salt stress) and favors general growth by preventing sodium accumulation in plants (PubMed:20088904). Required for microbe-associated molecular patterns (MAMPs)- and salicylic acid (SA)-dependent hypersensitive cell death (HR), involving indole glucosinolate breakdown products (e.g. indole-3-acetonitrile), probably in a PEN2 myrosinase-dependent metabolic pathway, triggered by the recognition of effectors from incompatible pathogens including oomycetes and bacteria (e.g. AvrRpm1 and AvrRps4) and benzothiadiazole- (BTH), and leading to an induced protection against pathogens (e.g. Pseudomonas syringae pv. tomato DC3000, Golovinomyces orontii and Hyaloperonospora arabidopsidis) (PubMed:23815470, PubMed:24889055, PubMed:26023163, PubMed:28434950)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Golgi apparatus, trans-Golgi network membrane. Endoplasmic reticulum membrane
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