Protein Name:
Methylthioribulose-1-phosphate dehydratase
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UniprotKB/SwissProt ID: Q9WVQ5 (Q9WVQ5)
Gene Name:
Apip
Organism: Mus musculus (Mouse)
Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9WVQ5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
146 |
HQEMIKGIRK C TSGGYYRYDD |
CCCCCCCCCC C CCCCCCCCCC |
2.35% |
21278135
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| 2 |
187 |
AHAMNEYPDS C AVLVRRHGVY |
CCCCCCCCCC C CCCCCCCCCC |
3.86% |
21278135
|
| 3 |
75 |
ERIQPEDMFV C DINEQDISGP |
CCCCCCCCCC C CCCCCCCCCC |
2.73% |
21278135
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| 4 |
96 |
PASKKLKKSQ C TPLFMNAYTM |
CCCCCCCCCC C CCCCCCCCCC |
5.66% |
21278135
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