Protein Name:
Protein kinase C and casein kinase substrate in neurons protein 2
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UniprotKB/SwissProt ID: Q9WVE8 (Q9WVE8)
Gene Name:
Pacsin2
Organism: Mus musculus (Mouse)
Function: Regulates the morphogenesis and endocytosis of caveolae (PubMed:21807942). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (PubMed:33972531)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane. Cell projection, ruffle membrane. Early endosome. Recycling endosome membrane. Cell membrane. Cell projection. Membrane, caveola. Cell junction, adherens junction
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9WVE8
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
38 |
VKRIDDGHRL C GDLMNCLHER |
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