Protein Name:
Mitotic checkpoint protein BUB3
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UniprotKB/SwissProt ID: Q9WVA3 (Q9WVA3)
Gene Name:
Bub3
Organism: Mus musculus (Mouse)
Function: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1 (By similarity). Regulates chromosome segregation during oocyte meiosis
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome, centromere, kinetochore
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9WVA3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
129 |
TVKLWDPRTP C NAGTFSQPEK |
CCCCCCCCCC C CCCCCCCCEE |
5.57% |
21278135
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