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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glycerol kinase 2

UniprotKB/SwissProt ID: Q9WU65 (Q9WU65)

Gene Name: Gk2

Organism: Mus musculus (Mouse)

Function: Key enzyme in the regulation of glycerol uptake and metabolism. Essential for male fertility and sperm mitochondrial sheath formation (PubMed:28852571, PubMed:30662012). Required for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during spermatogenesis (PubMed:30662012). Can induce mitochondrial clustering through interactions with PLD6 and up-regulation of phosphatidic acid synthesis in the mitochondria (PubMed:28852571)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion outer membrane. Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR043129 ATPase_NBD
IPR000577 Carb_kinase_FGGY
IPR018483 Carb_kinase_FGGY_CS
IPR018485 FGGY_C
IPR018484 FGGY_N
IPR042018 GK1-3_metazoan-type
IPR005999 Glycerol_kin

The S-nitrosylation sites of Q9WU65

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 381 YWEPSARGII C GLTQFTNKCH  CCCCCCCCCC C CCEEEEECCC  3.27% 21278135