UniprotKB/SwissProt ID: Q9W596 (Q9W596)
Gene Name:
futsch
Organism: Drosophila melanogaster (Fruit fly)
Function: During embryogenesis, necessary for dendritic and axonal organization and growth at the neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton (PubMed:10839355, PubMed:10839356, PubMed:11733059). Microtubule hairpin loops are found within a small subset of synaptic boutons at the neuromuscular synapse, these loops are stabilized by futsch (PubMed:10839355, PubMed:10839356, PubMed:11733059). Loop morphology and dynamics suggest that rearrangement of these microtubule-based loops is a critical component of the process of bouton division and for subsequent nerve-terminal growth and branching (PubMed:10839355, PubMed:10839356, PubMed:11733059). Translation is repressed by Fmr1 (PubMed:10839355, PubMed:10839356, PubMed:11733059). Together with ringer, required for neuromuscular junction (NMJ) bouton growth by regulating synaptic microtubules (PubMed:31156389). Function with ringer in maintaining microtubule stability and dynamics, is essential for promoting axon regeneration in response to peripheral (PNS) and central nervous system (CNS) injury (PubMed:31919191). In response to axotomy, acts downstream of a stress response cascade involving Xbp1 splicing, to control axon regeneration (PubMed:31919191)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton
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