Protein Name:
Lysine--tRNA ligase
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UniprotKB/SwissProt ID: Q9W327 (Q9W327)
Gene Name:
LysRS
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cytoplasm, cytosol. Nucleus. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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