Protein Name:
UDP-glucose 4-epimerase
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UniprotKB/SwissProt ID: Q9W0P5 (Q9W0P5)
Gene Name:
Gale
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine (PubMed:20519568, PubMed:22654673). The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited (PubMed:22654673). Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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