UniprotKB/SwissProt ID: Q9VV43 (Q9VV43)
Gene Name:
ringer
Organism: Drosophila melanogaster (Fruit fly)
Function: Regulator of microtubules required for axonal extension during embryonic development and axon regeneration following injury (PubMed:27422099, PubMed:31919191). Promotes microtubule bundling and polymerization (PubMed:27422099). Together with futsch, required for neuromuscular junction (NMJ) bouton growth by regulating synaptic microtubules (PubMed:31156389). Function with futsch in maintaining microtubule stability and dynamics, is essential for promoting axon regeneration in response to peripheral (PNS) and central nervous system (CNS) injury (PubMed:31919191). In response to axotomy, acts downstream of a stress response cascade involving Xbp1 splicing, to control axon regeneration (PubMed:31919191)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, axon. Presynapse
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