Protein Name:
Serine protease inhibitor 88Ea
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UniprotKB/SwissProt ID: Q9VFC2 (Q9VFC2)
Gene Name:
Spn88Ea
Organism: Drosophila melanogaster (Fruit fly)
Function: Serine protease inhibitor with activity toward trypsin (PubMed:18956323). Negatively regulates the Toll signaling pathway and suppresses the expression of the antifungal peptide drosomycin (PubMed:19581577). Its negative regulation of the Toll signaling pathway also results in the inhibition of the melanization immune response via the phenoloxidase (PPO1) cascade (PubMed:19581577). Essential for unfolding and expansion of the wings after emergence from the pupal case (PubMed:18956323). May regulate the Toll pathway by blocking the proteolysis of the Toll ligand spz (PubMed:19581577)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
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Graphical Visualization of S-nitrosylation Sites:
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