UniprotKB/SwissProt ID: Q9VEZ3 (Q9VEZ3)
Gene Name:
msps
Organism: Drosophila melanogaster (Fruit fly)
Function: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization (Probable) (PubMed:10477755, PubMed:11433295, PubMed:15530399, PubMed:15775959, PubMed:16303556, PubMed:26953351, PubMed:32066907). Function in neurons is essential for adult survival, and is important for climbing behavior and activity (PubMed:37041188). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:16303556, PubMed:17889670). May act as a microtubule antipause factor that rapidly catalyzes the transition from pause to either growth or shrinkage (PubMed:15775959). Involved in mitotic spindle elongation (PubMed:16303556). Involved in the establishment of cell polarity and mitotic spindle orientation in neuroblasts (PubMed:26953351). Required for maintaining the bipolarity of acentrosomal meiotic spindles; the function is dependent on tacc and involves ncd (PubMed:11433295). Involved in oocyte microtubule cytoskeleton organization and bicoid mRNA localization (PubMed:15530399). Seems to be involved in elongation of kinetochore-derived microtubule fibers (PubMed:19836241). In fat body cells, essential component of perinuclear non-centrosomal microtubule-organizing centers (ncMTOCs) which function to accommodate the organization of microtubule (MT) networks to control nuclear positioning and dynein motor-based retrograde endosomal trafficking (PubMed:32066907). Within the ncMTOCs, Msp300 and shot anchors the ncMTOC at the nuclear surface and recruits the MT minus-end regulators Patronin and Nin for assembly, anchoring and/or stabilization of circumferential and radial MTs at the ncMTOCs (PubMed:32066907). Patronin, and perhaps Nin, then recruits msps to the ncMTOC where it is required for the gamma-tubulin-independent elongation and assembly of radial MTs (PubMed:32066907)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, perinuclear region
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