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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Thioredoxin-dependent peroxide reductase, mitochondrial

UniprotKB/SwissProt ID: Q9VEJ0 (Q9VEJ0)

Gene Name: Prx3

Organism: Drosophila melanogaster (Fruit fly)

Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:11677042). Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:11677042, PubMed:20869434, PubMed:23124252). May be involved in aging-associated changes in the responsiveness to oxidative stress (PubMed:23124252). Involved in the maintenance of global thiol redox homeostasis (PubMed:20869434). Functions in the central nervous system (CNS) and in motor neurons and is essential for normal motor function (PubMed:33585478, PubMed:33889951)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR000866 AhpC/TSA
IPR050217 Peroxiredoxin
IPR019479 Peroxiredoxin_C
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain