UniprotKB/SwissProt ID: Q9VCJ8 (Q9VCJ8)
Gene Name:
SPE
Organism: Drosophila melanogaster (Fruit fly)
Function: Endopeptidase which plays a key role in innate immunity by cleaving Tl ligand spz and thereby activating the Toll pathway in response to fungal and Gram-positive bacterial infections (PubMed:16399077, PubMed:16631589, PubMed:16996061, PubMed:18724373, PubMed:26843333). Acts downstream of pathogen recognition receptors PGRP-SA and GNBP1 and protease grass in response to Gram-positive bacterial infection (PubMed:16399077). Acts downstream of protease psh in response to fungal infection (PubMed:16399077)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
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