UniprotKB/SwissProt ID: Q9UQV4 (Q9UQV4)
Gene Name:
LAMP3
Organism: Homo sapiens (Human)
Function: Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction (PubMed:25681212). Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process (PubMed:24434718). Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway (PubMed:29056532). May also play a role in dendritic cell function and in adaptive immunity (PubMed:9768752) (Microbial infection) Plays a positive role in post-entry steps of influenza A virus replication, either virus uncoating, cytosolic transport, or nuclear import of viral components, and promotes nuclear accumulation of influenza nucleoprotein/NP at early stages of viral infection (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F (Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell surface. Lysosome membrane. Cytoplasmic vesicle membrane. Early endosome membrane
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