Protein Name:
Calcium/calmodulin-dependent protein kinase type II subunit alpha
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UniprotKB/SwissProt ID: Q9UQM7 (Q9UQM7)
Gene Name:
CAMK2A
Organism: Homo sapiens (Human)
Function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Synapse. Postsynaptic density. Cell projection, dendritic spine. Cell projection, dendrite
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9UQM7
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
280 |
WISHRSTVAS C MHRQETVDCL |
CCEEEECCCC H HHHHHHHHCC |
1.6% |
22178444
19101475
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| 2 |
6 |
-----MATIT C TRFTEEYQLF |
CCEEEECCCC H HHHHHHHHCC |
1.96% |
22178444
18271754
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