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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Ubiquitin carboxyl-terminal hydrolase 24

UniprotKB/SwissProt ID: Q9UPU5 (Q9UPU5)

Gene Name: USP24

Organism: Homo sapiens (Human)

Function: Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR016024 ARM-type_fold
IPR056850 ARM_UBP34_24_USP9X_Y
IPR038765 Papain-like_cys_pep_sf
IPR050164 Peptidase_C19
IPR001394 Peptidase_C19_UCH
IPR015940 UBA
IPR009060 UBA-like_sf
IPR029071 Ubiquitin-like_domsf
IPR055176 UBP24/USP9X/USP9Y_UBL
IPR047061 UBP24_Ubl
IPR033382 USP24_UBA
IPR018200 USP_CS
IPR028889 USP_dom

The S-nitrosylation sites of Q9UPU5

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 116 DAEKNDENGN C SGEGIEFPTT   
2 1202 DMARSCAKSF C ENFLKAGGLS   
3 1287 SRQTSRQMSL C GTPEKSSYRQ   
4 1333 EVSDFTSTVA C FMRLSWAAAA   
5 1362 SQPIKESNSL C PAGIRNRLSS   
6 1516 SQCMEYFDLR C QLLDDLTTSE   
7 1556 DNFEPNRTAE C ETSEADNILL   
8 1580 LRLIKTLLSL C GAEKEMLGSS   
9 1859 EVLEGSNAYY C EKCKEKRITV   
10 2008 DLNDETLEYE C FGGEYRPKVY