Protein Name:
LIM and calponin homology domains-containing protein 1
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UniprotKB/SwissProt ID: Q9UPQ0 (Q9UPQ0)
Gene Name:
LIMCH1
Organism: Homo sapiens (Human)
Function: Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton, stress fiber
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9UPQ0
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
140 |
IYWLGKAANS C TSYSGTTLNL |
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| 2 |
182 |
RSIRDSGYID C WDSERSDSLS |
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| 3 |
333 |
AESTSMFDMR C EEEAAVQPHS |
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| 4 |
577 |
VHREEEKERE C PTVAPAHSLT |
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| 5 |
669 |
PQHFTTTVTR C SPTVAFVEFP |
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| 6 |
863 |
GTMNKIDLGN C QDEKQDRRWK |
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