Protein Name:
E3 ubiquitin-protein ligase TRIM33
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UniprotKB/SwissProt ID: Q9UPN9 (Q9UPN9)
Gene Name:
TRIM33
Organism: Homo sapiens (Human)
Function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9UPN9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
582 |
VQTMQRGNMN C GAFQAHQMRL |
CCCCCCCCCC C CCCCCCCCCC |
2.64% |
22178444
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| 2 |
786 |
KQEPGTEDEI C SFSGGVKQEK |
CCCCCCCCCC C CCCCCCCCCC |
2.94% |
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| 3 |
943 |
DIGKPEVEYD C DNLQHSKKGK |
CCCCCCCCCC C CCCCCCCCCC |
3.51% |
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