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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Dual specificity protein phosphatase 12

UniprotKB/SwissProt ID: Q9UNI6 (Q9UNI6)

Gene Name: DUSP12

Organism: Homo sapiens (Human)

Function: Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm, cytosol

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR000340 Dual-sp_phosphatase_cat-dom
IPR016278 DUSP12
IPR029021 Prot-tyrosine_phosphatase-like
IPR000387 Tyr_Pase_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
IPR013087 Znf_C2H2_type

The S-nitrosylation sites of Q9UNI6

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 307 LGSFNWYGEQ C SCGRWITPAF   
2 97 ETDLLSHLDR C VAFIGQARAE