Protein Name:
Sorting nexin-6
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UniprotKB/SwissProt ID: Q9UNH7 (Q9UNH7)
Gene Name:
SNX6
Organism: Homo sapiens (Human)
Function: Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Early endosome. Early endosome membrane. Cytoplasmic vesicle. Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9UNH7
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
149 |
KTVAMHEVFL C RVAAHPILRR |
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| 2 |
264 |
ALGTQDSTDI C KFFLKVSELF |
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| 3 |
398 |
AKGNLQLLQN C LAVLNGDT-- |
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