UniprotKB/SwissProt ID: Q9UNA1 (Q9UNA1)
Gene Name:
ARHGAP26
Organism: Homo sapiens (Human)
Function: GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria (PubMed:38081847). Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V (PubMed:27512058) Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endosome membrane. Cytoplasm. Cell junction, focal adhesion. Cytoplasm, cytoskeleton
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