Protein Name:
E3 ubiquitin-protein ligase HECTD1
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UniprotKB/SwissProt ID: Q9ULT8 (Q9ULT8)
Gene Name:
HECTD1
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9ULT8
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
123 |
NRTSRDLAEQ C VKVLELICTR |
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| 2 |
2064 |
ALASGALPDW C EQLTSKCPFL |
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| 3 |
2071 |
PDWCEQLTSK C PFLIPFETRQ |
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| 4 |
209 |
DHQVSDGALR C FASLADRFTR |
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| 5 |
2195 |
FQRTDLGAWL C DDNFPDDESR |
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| 6 |
2224 |
KPPGYYVQRS C GLFTAPFPQD |
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| 7 |
2415 |
IEDLGLNFQF C PSSRIYGFTA |
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| 8 |
254 |
GGTVSGPSSA C KPGRSTTGAP |
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| 9 |
287 |
STIVSLLSTL C RGSPVVTHDL |
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| 10 |
316 |
IESALQGDER C VLDTMRLVDL |
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| 11 |
487 |
AILQSPGDWM C PVNKGDDKKK |
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| 12 |
58 |
CPPRTFLPAL C KIFLDESAPD |
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