Protein Name:
Kinase D-interacting substrate of 220 kDa
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UniprotKB/SwissProt ID: Q9ULH0 (Q9ULH0)
Gene Name:
KIDINS220
Organism: Homo sapiens (Human)
Function: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Late endosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9ULH0
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
324 |
NATMVRDILQ C NPDTEICTKD |
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