Protein Name:
Short transient receptor potential channel 5
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UniprotKB/SwissProt ID: Q9UL62 (Q9UL62)
Gene Name:
TRPC5
Organism: Homo sapiens (Human)
Function: Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:16284075, PubMed:38959890). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity). Acts on distinct neuronal populations in the hypothalamus to regulate innate behaviors including feeding, anxiety (flight/fight/fear), socialization, and maternal care (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9UL62
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
553 |
ETRAIDEPNN C KGIRCEKQNN |
CCCCEEEECC C CCCCCCCCCE |
5.62% |
22178444
16998480
17051229
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| 2 |
558 |
DEPNNCKGIR C EKQNNAFSTL |
CCCCEEEECC C CCCCCCCCCE |
7.87% |
22178444
16998480
17051229
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