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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Protein kinase C and casein kinase substrate in neurons protein 3

UniprotKB/SwissProt ID: Q9UKS6 (Q9UKS6)

Gene Name: PACSIN3

Organism: Homo sapiens (Human)

Function: Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cell membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The S-nitrosylation sites of Q9UKS6

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 231 MEDMEQAFET C QAAERQRLLF   
2 36 VQRVEDGHRL C GDLVSCFQER   
3 402 KMSEEDEQGW C QGQLQSGRIG   
4 421 IGLYPANYVE C VGA-------