Protein Name:
F-box only protein 2
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UniprotKB/SwissProt ID: Q9UK22 (Q9UK22)
Gene Name:
FBXO2
Organism: Homo sapiens (Human)
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Microsome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9UK22
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
137 |
PCGEEDLEGW C DVEHGGDGWR |
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| 2 |
215 |
DWYSGRSDAG C LYELTVKLLS |
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| 3 |
71 |
ALPAAELVQA C RLVCLRWKEL |
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