Protein Name:
Anaphase-promoting complex subunit 7
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UniprotKB/SwissProt ID: Q9UJX3 (Q9UJX3)
Gene Name:
ANAPC7
Organism: Homo sapiens (Human)
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC7 is not required for the assembly of the APC/C complex, but has an enzyme-substrate adapter activity mediating the processive ubiquitination of specific substrates (PubMed:34942119). Involved in brain development through the specific ubiquitination and clearance of MKI67 from constitutive heterochromatin after neuronal progenitors exit mitosis (PubMed:34942119)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9UJX3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
295 |
GRLEDVENLG C RLFNISDQHA |
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| 2 |
417 |
AQTLTLLATV C LEDPVTQEKA |
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| 3 |
475 |
LRNALANQSD C VLHRILGDFL |
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| 4 |
97 |
GNSASTPQSQ C LPSEIEVKYK |
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