Protein Name:
Methyl-CpG-binding domain protein 1
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UniprotKB/SwissProt ID: Q9UIS9 (Q9UIS9)
Gene Name:
MBD1
Organism: Homo sapiens (Human)
Function: Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus matrix. Nucleus speckle. Chromosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9UIS9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
525 |
VLTSPVLVPG C PSKAVDPGLP |
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