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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Leucyl-cystinyl aminopeptidase

UniprotKB/SwissProt ID: Q9UIQ6 (Q9UIQ6)

Gene Name: LNPEP

Organism: Homo sapiens (Human)

Function: Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane. Secreted

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR045357 Aminopeptidase_N-like_N
IPR042097 Aminopeptidase_N-like_N_sf
IPR024571 ERAP1-like_C_dom
IPR034016 M1_APN-typ
IPR001930 Peptidase_M1
IPR050344 Peptidase_M1_aminopeptidases
IPR014782 Peptidase_M1_dom
IPR027268 Peptidase_M4/M1_CTD_sf

The S-nitrosylation sites of Q9UIQ6

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 305 EPLAARSAFP C FDEPAFKATF   
2 35 PDVVDLAKEP C LHPLEPDEVE