Protein Name:
Tyrosine-protein kinase BAZ1B
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UniprotKB/SwissProt ID: Q9UIG0 (Q9UIG0)
Gene Name:
BAZ1B
Organism: Homo sapiens (Human)
Function: Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9UIG0
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1045 |
ARKPNLGLKS C DGNQELLNFL |
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| 2 |
120 |
IMTKYAVGEE C DFEVGKEKML |
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| 3 |
1348 |
SRRQSLELQK C EEILHKIVKY |
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| 4 |
1420 |
QVFTNAEVYN C RGSHVLSCMV |
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| 5 |
1435 |
VLSCMVKTEQ C LVALLHKHLP |
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| 6 |
156 |
EATEKKSDGA C DSPSSDKENS |
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| 7 |
497 |
DREDKRSALS C VISKTARLLS |
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| 8 |
953 |
DHTVSGDEDY C PRSKKANLGK |
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| 9 |
994 |
PKQGQNLWFL C DSQKELDELL |
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