Protein Name:
Exportin-7
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UniprotKB/SwissProt ID: Q9UIA9 (Q9UIA9)
Gene Name:
XPO7
Organism: Homo sapiens (Human)
Function: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9UIA9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
123 |
ARITKLGWFD C QKDDYVFRNA |
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| 2 |
194 |
SSLFDIFTLS C NLLKQASGKN |
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| 3 |
331 |
LSDPNNYHEF C RLLARLKSNY |
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| 4 |
43 |
ALVEFTNSPD C LSKCQLLLER |
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| 5 |
47 |
FTNSPDCLSK C QLLLERGSSS |
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| 6 |
525 |
EQDAMDGELV C RVLQLMNLTD |
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| 7 |
767 |
AIELWYHDPA C TTPVLKLMAE |
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