Protein Name:
DNA polymerase subunit gamma-2
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UniprotKB/SwissProt ID: Q9UHN1 (Q9UHN1)
Gene Name:
POLG2
Organism: Homo sapiens (Human)
Function: Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9UHN1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
278 |
MSPSNFSSSD C QDEEGRKGNK |
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