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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Prenylcysteine oxidase 1

UniprotKB/SwissProt ID: Q9UHG3 (Q9UHG3)

Gene Name: PCYOX1

Organism: Homo sapiens (Human)

Function: Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (PubMed:10585463, PubMed:11078725, PubMed:12186880). Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides (By similarity). Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded (PubMed:10585463)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Lysosome

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR036188 FAD/NAD-bd_sf
IPR010795 Prenylcys_lyase
IPR017046 Prenylcysteine_Oxase

The S-nitrosylation sites of Q9UHG3

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 258 WAVEGGNKLV C SGLLQASKSN  CCHHHHHHHH H HHHHHHHHHH  3.75% 19483679