Protein Name:
Cysteine and histidine-rich domain-containing protein 1
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UniprotKB/SwissProt ID: Q9UHD1 (Q9UHD1)
Gene Name:
CHORDC1
Organism: Homo sapiens (Human)
Function: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:20230755). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105). Involved in stress response (PubMed:20230755). Prevents tumorigenesis (PubMed:20230755)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9UHD1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
157 |
DNDEIKIGTS C KNGGCSKTYQ |
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| 2 |
176 |
YQGLESLEEV C VYHSGVPIFH |
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| 3 |
195 |
FHEGMKYWSC C RRKTSDFNTF |
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| 4 |
211 |
DFNTFLAQEG C TKGKHMWTKK |
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| 5 |
230 |
KKDAGKKVVP C RHDWHQTGGE |
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| 6 |
24 |
FDPETNSDDA C TYHPGVPVFH |
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| 7 |
42 |
VFHDALKGWS C CKRRTTDFSD |
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| 8 |
5 |
------MALL C YNRGCGQRFD |
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| 9 |
59 |
DFSDFLSIVG C TKGRHNSEKP |
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| 10 |
86 |
EVKTTEKKEL C ELKPKFQEHI |
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