Protein Name:
E3 ubiquitin-protein ligase makorin-1
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UniprotKB/SwissProt ID: Q9UHC7 (Q9UHC7)
Gene Name:
MKRN1
Organism: Homo sapiens (Human)
Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9UHC7
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
186 |
QPYCGRTAPS C TEAPLQGSVT |
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| 2 |
98 |
VVCKYFQRGY C IYGDRCRYEH |
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