Protein Name:
Signal recognition particle subunit SRP68
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UniprotKB/SwissProt ID: Q9UHB9 (Q9UHB9)
Gene Name:
SRP68
Organism: Homo sapiens (Human)
Function: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (PubMed:16672232, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus, nucleolus. Endoplasmic reticulum
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9UHB9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
247 |
VEEISPNIRY C AYNIGDQSAI |
CCCCCCCCCC C CCCCCCCCCC |
2.02% |
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| 2 |
344 |
ERLFESMLSE C RDAIQVVREE |
CCCCCCCCCC C CCCCCCCCCC |
4.24% |
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| 3 |
525 |
ELITQVRSEK C SLQAAAILDA |
CCCCCCCCCC C CCCCCCCCCC |
4.27% |
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| 4 |
562 |
KPLVERFETF C LDPSLVTKQA |
CCCCCCCCCC C CCCCCCCCCC |
5.71% |
19483679
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