Protein Name:
Scavenger receptor cysteine-rich domain-containing protein DMBT1
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UniprotKB/SwissProt ID: Q9UGM3 (Q9UGM3)
Gene Name:
DMBT1
Organism: Homo sapiens (Human)
Function: May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9UGM3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1036 |
DANVVCRQLG C GWAMSAPGNA |
CCHHHHHHHH H HHHHHHHCCC |
5.82% |
25040305
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| 2 |
1683 |
DANVVCRQLG C GWAMSAPGNA |
CCHHHHHHHH H HHHHHHHCCC |
5.82% |
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| 3 |
406 |
DANVVCRQLG C GWATSAPGNA |
CCHHHHHHHH H HHHHHHHCCC |
5.82% |
25040305
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| 4 |
905 |
DANVVCRQLG C GWATSAPGNA |
CCHHHHHHHH H HHHHHHHCCC |
5.82% |
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