Protein Name:
Nuclear RNA export factor 1
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UniprotKB/SwissProt ID: Q9UBU9 (Q9UBU9)
Gene Name:
NXF1
Organism: Homo sapiens (Human)
Function: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus, nucleoplasm. Nucleus speckle. Nucleus, nuclear pore complex. Nucleus envelope. Cytoplasm. Cytoplasm, Stress granule
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9UBU9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
143 |
AWLLSMIQSK C SVPFTPIEFH |
CCCCCCCCCC C CCCCCCCCHH |
6.33% |
24105792
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| 2 |
252 |
NIDVVLNRRS C MAATLRIIEE |
CCCCCCCCCC C CCCCCCCCHH |
1.72% |
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| 3 |
328 |
EELWLDGNSL C DTFRDQSTYI |
CCCCCCCCCC C CCCCCCCCHH |
4.68% |
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| 4 |
373 |
DVEAPTTLPP C KGSYFGTENL |
CCCCCCCCCC C CCCCCCCCHH |
8.02% |
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| 5 |
528 |
IAVPASNSGL C IVNDELFVRN |
CCCCCCCCCC C CCCCCCCCHH |
3.58% |
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| 6 |
588 |
SGMNLEWSQK C LQDNNWDYTR |
CCCCCCCCCC C CCCCCCCCHH |
2.98% |
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